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英语翻译Electron transfer at each step of the respiratory chain

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英语翻译
Electron transfer at each step of the respiratory chain is not completely efficient,resulting in the escape of electrons that reduce O2 to superoxide anion,which is converted to hydrogen peroxide by the action of manganese superoxide dismutase.These reactive oxygen species (ROS) have the potential to damage lipids,proteins,and nucleic acids,leading to cellular dysfunction or death.
Electron transport chain activity appears to be optimized for physiological PO2 and deviations from normal PO2 (in either direction) are associated with increased ROS production.The utilization of O2 for energy metabolism is a two-edged sword:the complete oxidation of glucose to CO2 and H2O greatly increases the yield of ATP as compared with the incomplete oxidation of glucose to lactate; however,the transfer
of electrons poses an inherent risk of ROS production.As a result,the cellular O2 concentration must be very tightly regulated through homeostatic mechanisms that control O2 delivery and O2 utilization.
英语翻译Electron transfer at each step of the respiratory chain
呼吸链每一步的电子转移并非完全高效的,会导致电子逃逸并将氧气还原成超氧阴离子自由基,通过锰超氧化物歧化酶的作用转化为过氧化氢.这些活性氧簇(ROS)有可能破坏脂类,蛋白质,核酸,导致细胞功能障碍或死亡.
随着活性氧簇的增加,生理氧分压的电子传递链活动似乎被优化了,从而偏离了正常氧分压(在任一方向).利用氧能量代谢是一把双刃剑:完整的葡萄糖氧化为二氧化碳和水和不完全氧化的葡萄糖转化成乳酸相比,大大增加了三磷酸腺苷产量,然而,电子传递存在着活性氧簇产生的潜在危险.因此,细胞氧气浓度必须通过稳态机制进行严密调节来控制氧输送和氧利用.