英语翻译肝细胞癌(HCC)是严重危害人类健康、也是全世界范围内最常见的恶性肿瘤之一.大量研究表明HBV感染所致肝细胞癌所

英语翻译
肝细胞癌(HCC)是严重危害人类健康、也是全世界范围内最常见的恶性肿瘤之一.大量研究表明HBV感染所致肝细胞癌所占的比例约是全球肝细胞癌发生数的75～85％,但HBV导致肝癌的具体发生机制一直未完全阐明[1].近来研究乙型肝炎病毒基因型,以及各种基因型HBV诱发肝癌的机制已成为当今研究的热点.国内外研究表明,HBV基因型可能与疾病进程、感染后临床表现、预后和抗病毒治疗应答等密切相关.目前普遍认为,基因型C引起的炎性坏死及纤维化程度比B型更加严重,且C型与肝硬化和肝癌有关;基因型B的累积生存率要明显高于C型.近来研究表明,HBV的变异率较其它DNA大约高10倍,HBV基因变异与疾病的临床转归相关,变异株可导致致病性和复制能力增加、改变宿主免疫应答的重要表位以及产生对抗病毒药物的耐药性.由于HBV的不同编码基因相互重叠,启动子和增强子等调控序列又位于编码基因之内,某个部位的基因突变将影响多个基因的表达,从而形成HBV基因变异[2,3],因此,更全面地研究乙型肝炎病毒基因组的变异及其生物学意义尤为重要.近年来国内外学者关于HBV基因型、变异位点与HCC关系的研究做了大量的工作 ,云南地区近年也有关于HBV基因型分布的研究报道,但是关于HBV基因型、变异位点与HCC关系的研究尚未见报道.本研究旨在了解云南地区慢性HBV感染者基因型感染情况,了解变异位点检测情况,探讨慢性HBV感染者基因型、常见变异位点与肝细胞癌的关系.

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumor all over the world.It is a serious hazard to human health.A large number of studies have indicated that HBV infection contributes 75-80% of hepatocellular carcinoma in the world.the specific HBV infection has not been well elucidated yet.[1] Recent study hot points focused on hepatitis B virus genotypes and various genotypes of the mechanism of HBV induced liver cancer.The international research shows that HBV genotype may be associated with disease progression after infection clinical presentation,prognosis and treatment response and other anti-virus.It is widely agreed that inflammatory necrosis and fibrosis caused by genotype C is more severe than that caused by genotype B.Genotype C is related to liver cirrhosis and cancer.The cumulative survival rate of genotype B is significantly higher than genotype C.Recent studies showed that,the mutation rate of HBV is about 10 times higher than other DNA.HBV variation is related to clinical outcome.The mutated HBV can lead to increased pathogenicity and replicationan ability,important token of the host immune response against the epitopes and the generation HIV drug resistance.Because the different gene encodings of HBV are overlapped and the promoter and enhancer regulatory sequences are located within the gene encoding,one part of the gene mutation will affect the expression of multiple genes.Thus the HBV gene mutation is formed [2,3].Then it is very important to carry on systemic study of hepatitis B virus genome variability and its biological significance.A lot of work has been done on HBV genotype and relationship between mutation position and HCC in recent years.The research on distribution of HBV genotypes has been reported in Yunnan.Nervertheless,the HBV genotype and relationship between mutation position and HCC have not been reported yet.This study aimed on chronic HBV infection in Yunnan genotype infection to understand the detection of variable sites,explore the genotype of chronic HBV infection and the relationship between common variable sites and hepatocellular carcinoma.